Conditional logistic regression analysis was used to examine the effects of CHP use on the odds of miscarriage and preterm birth. ![]() All participants were followed up to perinatal outcomes. A propensity score (PS)-matched cohort (6,192 pairs) was established based on baseline confounders. According to the medical use of tocolytics and CHP, we divided the users into two groups: western medicine (WM) only (n = 40,961) and WM/CHP (n = 6,192) groups. A total of 47,153 pregnant women treated with tocolytics aged 18–50 years from 2001 to 2015 were selected from two million random samples. Materials and Methods: We conducted a retrospective cohort study based on the National Health Insurance Research Database. The goal was to evaluate the efficacy of combined tocolytic therapy and CHP therapy in pregnancy outcomes for pregnant women in Taiwan. Chinese herbal products (CHP) are used as alternative therapies for pregnant women. However, previous reports have shown that progestogen might not be effective and ritodrine may increase the risk of maternal vascular-related diseases. Introduction: Tocolytic treatment is beneficial to pregnant women with a risk of premature labor or miscarriage. 7Department of Chinese Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.6Department of Public Health, College of Medicine, Tzu Chi University, Hualien, Taiwan.5Department of Obstetrics and Gynecology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.4Department of Medical Research, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.3Sports Medicine Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. ![]() 2School of Post-baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan.1Department of Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.Hsuan-Shu Shen 1,2,3 Wei-Chuan Chang 4 Yi-Lin Chen 5 Dai-Lun Wu 6 Shu-Hui Wen 6 Hsien-Chang Wu 2,7*
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